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  <url>
    <loc>https://www.vermalab.org/home-page</loc>
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    <lastmod>2021-08-05</lastmod>
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  <url>
    <loc>https://www.vermalab.org/research</loc>
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    <lastmod>2021-08-05</lastmod>
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      <image:title>Research - What dictates cellular responses to chemotherapies that target DNA repair pathways? DNA repair pathways have been the target of multiple FDA-approved and experimental chemotherapies. The success of these therapies depends on the increased reliance of rapidly proliferating cancer cells on DNA replication and repair pathways. However, holistic responses to chemotherapies are an amalgamation of multiple cellular pathways and physiological settings. We are interested in decoding the molecular determinants that dictate chemotherapeutic response with the broad goal of tailoring treatment regimens and uncovering biological circuits that ensure genomic stability.</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/60ecc937944713055fb764de/1626650081962-QNEVUP632Z6N0E4SJIPK/REPLISOME_2.jpg</image:loc>
      <image:title>Research - How cancer cells deal with roadblocks to replication?   Oncogenic transformations are often associated with genomic alterations that can challenge DNA replication.  Owing to the essentiality of genome duplication for cell survival, cancers evolve pathways to surmount obstacles to replication. Intriguingly, depending on the cellular context, these obstacles come in “different flavors”. By designing genetically defined systems to mimic different replication stress responses, the lab aims to define genome rescue mechanisms that are common and unique across cancer types.</image:title>
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      <image:title>Research - What are the endogenous DNA lesions in BRCA-mutant cancer cells?   Cancers are characterized by aberrations in chromosomal numbers and characteristic DNA lesions, including damaged replication forks, single-strand breaks and double-strand breaks. The endogenous sources of these abnormalities remain unclear. In theory, any unresolved chemical modification in the nucleotide backbone of DNA can be the initiating molecular event for genomic instability when HR fails. We are interested in examining the unexplored link between nucleotide abnormalities and oncogenic transformations in HR-deficient cancers. These findings can be the key to understanding the innate molecular events that led to malignancy, and perhaps also reveal the basis for the known predilection of HR deficiency to result in cancers only in specific tissue types. This information can result in the discovery of biomarkers that can aid in the early detection of cancer. It may also be used to avoid exogenous exposures that lead to the genesis of such precipitating lesions.</image:title>
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    <lastmod>2026-01-11</lastmod>
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  <url>
    <loc>https://www.vermalab.org/methodologies</loc>
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    <lastmod>2021-08-05</lastmod>
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      <image:title>Methodologies</image:title>
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  <url>
    <loc>https://www.vermalab.org/resources</loc>
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    <priority>0.75</priority>
    <lastmod>2025-04-21</lastmod>
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  <url>
    <loc>https://www.vermalab.org/gallery-1</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2026-03-16</lastmod>
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      <image:title>News</image:title>
      <image:caption>2025-Holiday Blast in The Wicked Lab!</image:caption>
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      <image:caption>Fun at the CSH meeting and in NYC!</image:caption>
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      <image:caption>SUMMER 2025: bbq with fireworks, B'day celebrations and many more...</image:caption>
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      <image:caption>May 2025: Kevin's Farewell. Sam sets the record for sushi!</image:caption>
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      <image:caption>Jan-April 2025: CGI retreat, Wally's trip and many more..</image:caption>
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      <image:title>News</image:title>
      <image:caption>Dumpling's for labs giving and yes we introduced "VERMIES"-one-of-a-kind award that recognizes your unique potential in the lab!</image:caption>
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      <image:caption>Halloween celebrations 2024!</image:caption>
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      <image:caption>Lab hiking at Castlewood and bbq at Dalie's!</image:caption>
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      <image:caption>2024 Annual BBQ blast!</image:caption>
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      <image:caption>Fun March 2024: CGI retreat, Kevin's perfect MCAT score, Lindsey's birthday and lab's trip to WALLY'S</image:caption>
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      <image:caption>Funtime at the EMBO meeting in India!</image:caption>
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      <image:caption>Lindsey passes her QE!!</image:caption>
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      <image:caption>2023 holiday celebration. Thanks Taylor for Barbie pipette!</image:caption>
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      <image:caption>Lovely Nov.2023: Lindsey's bridal shower and Lab's giving</image:caption>
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      <image:caption>Celebrating Natasha's thesis committee presentation @Puttshack</image:caption>
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      <image:caption>Our first BBQ party was a blast!</image:caption>
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      <image:caption>Busy September: Celebrating all Virgos and BBSB retreat!</image:caption>
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      <image:caption>Lab outing on the 2nd b'day of the Verma lab</image:caption>
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      <image:caption>Lab at 2023 Midwest DNA repair conference</image:caption>
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      <image:title>News</image:title>
      <image:caption>2023 CGI Annual Retreat</image:caption>
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      <image:title>News</image:title>
      <image:caption>Thank you Lindsey for the personalized Verma Lab mugs!!</image:caption>
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      <image:caption>Verma lab ritual: Playing Codename!</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/60ecc937944713055fb764de/c44d43ba-f581-4305-8b49-d878dd2e93ed/IMG_5201.jpeg</image:loc>
      <image:title>News</image:title>
      <image:caption>Happy Holidays, 2022!</image:caption>
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      <image:caption>Ladies in Black-At the Oncology Holiday Party!</image:caption>
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      <image:caption>Brewery Lights 2022!</image:caption>
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      <image:caption>White elephant with Vindigni lab</image:caption>
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      <image:caption>Happy Holidays!</image:caption>
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      <image:caption>Welcome Kevin, Ayda, Tessa, and Sham!</image:caption>
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      <image:caption>Happy Birthday, Taylor!</image:caption>
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      <image:caption>Lab at CGI retreat 2022</image:caption>
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      <image:caption>Shakespeare in the park</image:caption>
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      <image:caption>Lab is 1 year old now!</image:caption>
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      <image:title>News</image:title>
      <image:caption>Thanks, Taylor, for the yummy cupcakes!</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/60ecc937944713055fb764de/1391fc8a-284f-409f-8497-43ecaa04677c/IMG_4892.jpeg</image:loc>
      <image:title>News</image:title>
      <image:caption>Happy Birthday, Ena!</image:caption>
    </image:image>
    <image:image>
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      <image:title>News</image:title>
      <image:caption>Mentor-Mentee team rocked at MGG retreat!</image:caption>
    </image:image>
    <image:image>
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      <image:title>News</image:title>
      <image:caption>Ayda rocked at the Cancer Symposium!</image:caption>
    </image:image>
  </url>
</urlset>

